Peptic ulcer is an illness which is considerably prevalent in a large number of people worldwide. It occurs primarily in that part of G.I.T which is exposed to gastric acid and pepsin i.e. the stomach and duodenum. The major etiological factors of this disorder include stress, smoking, nutritional deficiencies, infections, frequent and indiscriminate use of NSAID’S. The pathogenesis of gastrointestinal disorders is influenced by both aggressive factors (like increased acid-pepsin secretion, bile salts, H.pylori etc.) and defensive factors (such as mucus secretion, mucosal barrier, blood flow, cellular regeneration , endogenous protective agents, prostaglandins and epidermal growth factors). Many allopathic synthetic drugs like proton pump inhibitors , H¬2 receptor antagonists are available in the market but these fail to provide a complete & safe cure. Thus an urgent requirement for safe and efficacious anti-ulcer agent is the necessity of time. Indian medicinal plants, herbs offer a potential solution to combat such disorder. This present article reviews anti-secretory, ulcer-healing and anti-oxidant properties of not only some of the Indigenous herbs but also those available worldwide. To achieve this objective, published literature and reports were studied intensively to consolidate information on the herbs with potential anti-ulcer activity. Eruca sativa, Musa sapientum, Eugenia jambolana, Trigonella foenum along with many others have been summarized in this article.
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